Dr. Justin Grodin, a cardiologist and co-director of the UT Southwestern Multidisciplinary Amyloidosis Program, goes through the diagnostic process for AL and ATTR cardiac amyloidosis. He discusses key differences between AL and ATTR, and how typing of amyloidosis is paramount to consider in order to subsequently develop a treatment plan. He goes through a diagnostic algorithm to help clinicians arrive at an accurate diagnosis. Finally, he stresses the importance of genetic testing and counseling for ATTR to differentiate between wild-type and hereditary, as well as identifying the specific genetic variant.